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Brian Rappold

Brian Rappold is the Director of Mass Spectrometry at LabCorp. He currently serves as the clinical chemistry chair for the American Society for Mass Spectrometry as well as on the scientific committees for endocrinology and small molecule analysis/toxicology for Mass Spectrometry: Applications to the Clinical Laboratory (MSACL). He has published scientific articles and presented his research at international conventions on topics including hydrophilic interaction liquid chromatography for bio-analysis, multiplexed mass spectrometric detection of amino acidopathies, and the origins and solutions of ion suppression in electrospray ionization. He is a recognized expert in the field of method development and validation of mass spectrometry assays for clinical diagnostic use, teaching courses on the topic at numerous scientific conferences.

Rappold also co-authored the chapter “Development and Validation of Small Molecule Analytes By Liquid Chromatography-Tandem Mass Spectrometry” in the 6th edition of the Tietz Textbook of Clinical Chemistry and Molecular Diagnostics (2016). This classic chemistry reference is considered the most current and authoritative guidance on selecting, performing, and evaluating the results of new and established laboratory tests.

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